Characterization of the proteins of human synovial fluid in certain disease states.

In search of the similarities and differences between blood plasma and synovial fluid, on one hand, and normal and pathological joint fluid on the other, it appeared important to investigate systematically the protein components of joint fluid. Investigations of the synovial fluid proteins by electrophoresis have been carried out by several authors (1-4). The identification of these proteins has been initiated (1, 5). Fractionation with ammonium sulfate to obtain the albuminglobulin ratio (6) and demonstration of definite properties of certain proteins by immunochemical methods and enzymatic reactions have been reported (1, 5). This publication presents a study on the characterization of the proteins in pathological synovial fluids.